Protective effects of spironolactone against anthracycline-induced cardiomyopathy
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چکیده
منابع مشابه
Protective effects of carvedilol against anthracycline-induced cardiomyopathy.
OBJECTIVES The aim of this study was to determine the protective effect of carvedilol in anthracycline (ANT)-induced cardiomyopathy (CMP). BACKGROUND Despite its broad effectiveness, ANT therapy is associated with ANT-induced CMP. Recent animal studies and experimental observations showed that carvedilol prevented development of CMP due to chemotherapeutics. However, there is no placebo-contr...
متن کاملManagement options Anthracycline-induced cardiomyopathy
Anthracycline cardiomyopathy is less frequently encountered nowadays, due to the well-recognised dose limitations and cardiac monitoring protocols used by chemotherapy centres. However, it is a condition that will persist due to the sensitivity of some patients to these drugs and the necessity for large doses to be used for certain individuals. We have demonstrated the benefit of angiotensin-co...
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Objective(s): Cirrhotic cardiomyopathy refers to cardiac muscle dysfunction caused by liver cirrhosis. Seemingly, free radicals and inflammatory factors play a critical role in the pathophysiology of cardiomyopathy. Curcumin has the anti-inflammatory, antioxidant, and anticancer properties . However, the therapeutic indications of this compound are limited due to its low absorption, rapid metab...
متن کاملRadio-protective effects of Hesperidin against gamma radio-radio-protective effects of Hesperidin against gamma radiation induced histopathological changes in the liver of Sprague Dawely rats
Introduction: Despite the extensive use of ionizing radiation in diagnosis and therapeutic procedures, development of radio-protector agents is important in modulating normal tissue damages. Hesperidin(HES) is a Flavanone glycoside, belonging to the Flavonoid family in human diet abundantly and noted for its many beneficial effects. The aim of present study was investigated to ...
متن کاملEfficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy.
m g o d 0 m v s To the Editor: Antineoplastic agents of the anthracycline (ANT) group are commonly and effectively used in various forms of malignancies. Anthracyclines might lead to irreversible cardiomyopathy (CMP), despite their beneficial effects. A number of mechanisms, such as elevation in free superoxide anion radicals, apoptosis, and mitochondrial dysfunction have been implicated in ANT...
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ژورنال
عنوان ژورنال: European Journal of Heart Failure
سال: 2014
ISSN: 1388-9842
DOI: 10.1002/ejhf.196